{"id":2412,"date":"2019-05-09T03:40:52","date_gmt":"2019-05-09T03:40:52","guid":{"rendered":""},"modified":"2019-05-09T11:41:20","modified_gmt":"2019-05-09T03:41:20","slug":"%e5%a4%9a%e5%99%a8%e5%ae%98%e5%be%ae%e6%b5%81%e6%8e%a7%e8%8a%af%e7%89%87%e6%8a%80%e6%9c%af%e5%8f%8a%e5%85%b6%e5%ba%94%e7%94%a8","status":"publish","type":"post","link":"http:\/\/www.szryc.com\/?p=2412","title":{"rendered":"\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u6280\u672f\u53ca\u5176\u5e94\u7528"},"content":{"rendered":"

\n\t\u5fae\u6d41\u63a7\u82af\u7247\u6280\u672f\uff08MI<\/u>crofluidics\uff09\u4e5f\u88ab\u79f0\u4e3a\u82af\u7247\u5b9e\u9a8c\u5ba4\uff08Lab-On-a-Chip, LOC\uff09\uff0c\u6d89\u53ca\u7269\u7406\u3001\u5316\u5b66\u3001\u533b\u5b66\u3001\u6d41\u4f53\u3001\u7535\u5b50\u3001\u6750\u6599\u3001\u673a\u68b0<\/u>\u7b49\u591a\u5b66\u79d1\u4ea4\u53c9\u7684\u7814\u7a76\u9886\u57df\u3002\u901a\u8fc7\u5fae\u901a\u9053\u3001\u53cd\u5e94\u5ba4\u548c\u5176\u4ed6\u67d0\u4e9b\u529f\u80fd\u90e8\u4ef6\uff0c\u5bf9\u6d41\u4f53\u8fdb\u884c\u7cbe\u51c6\u64cd\u63a7\uff0c\u5bf9\u751f\u7269\u3001\u5316\u5b66\u3001\u533b\u5b66\u5206\u6790\u8fc7\u7a0b\u7684\u6837\u54c1\u5236\u5907\u3001\u53cd\u5e94\u3001\u5206\u79bb\u3001\u68c0\u6d4b\u7b49\u57fa\u672c\u64cd\u4f5c\u5355\u5143\u96c6\u6210\u5206\u6790\uff0c\u5177\u6709\u6db2\u4f53\u6d41\u52a8\u53ef\u63a7\u3001\u96c6\u6210\u5316\u3001\u6d88\u8017\u4f4e\u3001\u901a\u91cf\u9ad8\u3001\u5206\u6790\u5feb\u7b49\u4f18\u70b9\uff0c\u5df2\u7ecf\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u751f\u7269\u533b\u5b66\u548c\u73af\u5883\u79d1\u5b66\u7b49\u7814\u7a76\u9886\u57df\u3002\u57fa\u4e8e\u5fae\u6d41\u63a7\u82af\u7247\u6280\u672f\u7684\u4eba\u4f53\u5668\u5b98\u82af\u7247\uff08Human organs-on-chips\uff09\u8fd1\u51e0\u5e74\u6765\u53d1\u5c55\u8fc5\u901f\uff0c\u5df2\u7ecf\u5b9e\u73b0\u80ba\u3001\u80be\u3001\u80a0\u3001\u809d\u3001\u5fc3\u810f\u3001\u8840\u7ba1\u3001\u76ae\u80a4\u3001\u5927\u8111\u3001\u9aa8\u9abc\u3001\u4e73\u817a\u3001\u813e\u810f\u3001\u8840\u8111\u5c4f\u969c\u3001\u6c14\u8840\u5c4f\u969c\u7b49\u82af\u7247\u7684\u6784\u5efa\uff0c\u901a\u8fc7\u4e0e\u7ec6\u80de\u751f\u7269\u5b66\u3001\u5de5\u7a0b\u5b66\u548c\u751f\u7269\u6750\u6599\u7b49\u591a\u79cd\u5b66\u79d1\u7684\u65b9\u6cd5\u76f8\u7ed3\u5408\uff0c\u4f53\u5916\u6a21\u62df\u591a\u79cd\u6d3b\u4f53\u7ec6\u80de\u3001\u7ec4\u7ec7\u5668\u5b98\u5fae\u73af\u5883\uff0c\u53cd\u6620\u4eba\u4f53\u7ec4\u7ec7\u5668\u5b98\u7684\u4e3b\u8981\u7ed3\u6784\u548c\u529f\u80fd\u7279\u5f81\u3002<\/p>\n

\n\t\u4eba\u4f53\u4e0d\u540c\u5668\u5b98\u6216\u6574\u4e2a\u7cfb\u7edf\u7684\u6bd2\u6027\u68c0\u6d4b\u662f\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u5b66\u7814\u7a76\u7684\u91cd\u8981\u90e8\u5206\uff0c\u4f20\u7edf\u7684\u4e8c\u7ef4\u7ec6\u80de\u57f9\u517b\u6a21\u5f0f\u4ee5\u53ca\u52a8\u7269\u5b9e\u9a8c\u53d6\u5f97\u4e86\u8bf8\u591a\u6210\u5c31\uff0c\u4f46\u53d7\u5468\u671f\u3001\u6210\u672c\u3001\u7cbe\u51c6\u5ea6\u3001\u4f26\u7406\u7b49\u56e0\u7d20\u7684\u9650\u5236\uff0c\u96be\u4ee5\u9884\u6d4b\u4eba\u4f53\u5bf9\u4e8e\u5404\u79cd\u836f\u7269\u7684\u54cd\u5e94\u3002\u7814\u7a76\u8868\u660e\uff1a\u4eba\u4f53\u5668\u5b98\u82af\u7247\u6280\u672f\u80fd\u51c6\u786e\u5730\u63a7\u5236\u591a\u4e2a\u7cfb\u7edf\u53c2\u6570\uff0c\u4e0e\u4f20\u7edf\u7684\u6bd2\u7406\u5b66\u52a8\u7269\u5b9e\u9a8c\u76f8\u6bd4\u66f4\u80fd\u53cd\u6620\u4eba\u4f53\u5185\u771f\u5b9e\u60c5\u51b5\uff0c\u5728\u65b0\u836f\u7b5b\u9009\u65b9\u9762\u66f4\u5177\u7279\u5f02\u6027\u3002\u56e0\u6b64\uff0c\u5229\u7528\u5fae\u52a0\u5de5\u6280\u672f\uff0c\u5efa\u7acb\u66f4\u63a5\u8fd1\u4eba\u4f53\u73af\u5883\u7684\u4eff\u751f\u7cfb\u7edf\u6210\u4e3a\u4f53\u5916\u751f\u7406\u6a21\u578b\u7684\u7814\u7a76\u70ed\u70b9\u3002<\/p>\n

\n\t <\/div>\n

\n\t\u7136\u800c\uff0c\u968f\u7740\u5668\u5b98\u82af\u7247\u6280\u672f\u7684\u53d1\u5c55\uff0c\u5176\u5e94\u7528\u4ecd\u7136\u5b58\u5728\u4e00\u5b9a\u7684\u5c40\u9650\u6027\uff0c\u5927\u90e8\u5206\u751f\u7406\u9014\u5f84\u9700\u8981\u8fde\u7eed\u4ecb\u8d28\u5faa\u73af\u548c\u7ec4\u7ec7\u95f4\u76f8\u4e92\u4f5c\u7528\uff0c\u5355\u5668\u5b98\u82af\u7247\u65e0\u6cd5\u5168\u9762\u53cd\u6620\u673a\u4f53\u5668\u5b98\u529f\u80fd\u7684\u590d\u6742\u6027\u3001\u529f\u80fd\u53d8\u5316\u548c\u5b8c\u6574\u6027\u3002\u4e3a\u9002\u5e94\u4eba\u4f53\u7ed3\u6784\u590d\u6742\u6027\uff0c\u672a\u6765\u7684\u7814\u7a76\u9700\u8981\u5efa\u7acb\u66f4\u52a0\u590d\u6742\u7684\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\uff08Multi<\/u>-Organ-Chip, MOC\uff09\u7cfb\u7edf\uff0c\u5c06\u51e0\u79cd\u5668\u5b98\u7b49\u540c\u7269\u5408\u5e76\u5230\u7c7b\u4f3c\u4eba\u7c7b\u7684\u4ee3\u8c22\u73af\u5883\u4e2d\uff0c\u5f00\u53d1\u52a8\u6001\u7684\u5b9e\u9a8c\u5ba4\u5fae\u751f\u7269\u53cd\u5e94\u5668\uff0c\u8fdb\u884c\u7cfb\u7edf\u7684\u6bd2\u6027\u68c0\u6d4b\u548c\u4ee3\u8c22\u8bc4\u4f30\u3002<\/p>\n

\n\t\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u7684\u8bbe\u8ba1\u539f\u7406<\/strong><\/p>\n

\n\t\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u5c06\u4e0d\u540c\u5668\u5b98\u548c\u7ec4\u7ec7\u7684\u7ec6\u80de\u5728\u82af\u7247\u4e0a\u57f9\u517b\uff0c\u4ee5\u5fae\u901a\u9053\u76f8\u8fde\uff0c\u5b9e\u73b0\u591a\u5668\u5b98\u96c6\u6210\u5316\uff0c\u4ee5\u8003\u5bdf\u5176\u76f8\u4e92\u4f5c\u7528\u6216\u5efa\u7acb\u4e00\u4e2a\u7cfb\u7edf\uff0c\u7528\u4e8e\u4f53\u5916\u836f\u7269\u7b5b\u9009\u3002\u82af\u7247\u4e2d\u53ef\u96c6\u6210\u6570\u4e2a\u7ecf\u8fc7\u7279\u6b8a\u8bbe\u8ba1\u7684\u5fae\u57f9\u517b\u5ba4\u3001\u704c\u6ce8\u901a\u9053\u5e76\u540c\u65f6\u57f9\u517b\u591a\u79cd\u7ec6\u80de\uff0c\u5229\u7528\u5fae\u6d41\u63a7\u6280\u672f\u53ef\u4ee5\u4ea7\u751f\u7cbe\u786e\u53ef\u63a7\u7684\u6d41\u4f53\u526a\u5207\u529b\u3001\u5468\u671f\u6027\u53d8\u5316\u7684\u673a\u68b0\u529b\u548c\u6eb6\u8d28\u6d53\u5ea6\u68af\u5ea6\u53d8\u5316\u7684\u704c\u6ce8\u6db2\u3002\u5229\u7528\u8fd9\u4e9b\u5e73\u53f0\u4f18\u52bf\uff0c\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u53ef\u4ee5\u7528\u4e8e\u7ec6\u81f4\u5730\u5206\u6790\u7ec4\u7ec7\u3001\u5668\u5b98\u7279\u5f02\u6027\u5e94\u6fc0\u53cd\u5e94\uff0c\u4f8b\u5982\u5faa\u73af\u514d\u75ab\u7ec6\u80de\u7684\u52df\u96c6\u3001\u5bf9\u836f\u7269\u3001\u6bd2\u7d20\u6216\u5176\u4ed6\u523a\u6fc0\u56e0\u7d20\u7684\u5e94\u7b54\u7b49\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u5c06\u591a\u4e2a\u6a21\u62df\u4e0d\u540c\u5668\u5b98\u3001\u7ec4\u7ec7\u7684\u82af\u7247\uff0c\u6309\u7167\u4f53\u5185\u7684\u5173\u7cfb\uff0c\u7528\u8840\u7ba1\u5185\u76ae\u7ec4\u7ec7\u3001\u8840\u7ec6\u80de\u6216\u662f\u6d41\u4f53\u4ecb\u8d28\u5c06\u5176\u8fde\u63a5\u8d77\u6765\uff0c\u5c31\u80fd\u5728\u4f53\u5916\u6a21\u4eff\u4f53\u5185\u4e0d\u540c\u5668\u5b98\u3001\u7ec4\u7ec7\u4e4b\u95f4\u7684\u751f\u7406\u4f5c\u7528\u548c\u836f\u7269\u5206\u5e03\u7b49\u3002 <\/p>\n

\n\t\u56fe1\u6240\u793a\u4e3a MOC\u7cfb\u7edf\u88c5\u7f6e\uff0c\u56fe1\uff08a\uff09\u5305\u62ec\u4e24\u4e2a\u805a\u78b3\u9178\u916f\u76d6\u677f\uff0cPDMS-\u73bb\u7483\u82af\u7247\u7528\u4e8e\u627f\u8f7d\u8840\u6d41\u56de\u8def\uff08\u7c89\u7ea2\u8272\uff09\u548c\u6392\u6cc4\u6d41\u52a8\u56de\u8def\uff08\u9ec4\u8272\uff09\uff1b\u6570\u5b57\u5206\u522b\u4ee3\u8868\u80a0\u9053\uff081\uff09\uff0c\u809d\u810f\uff082\uff09\uff0c\u76ae\u80a4\uff083\uff09\u548c\u80be\u810f\uff084\uff09\u7ec4\u7ec7\u76844\u4e2a\u7ec4\u7ec7\u57f9\u517b\u9694\u5ba4\u3002\u591a\u5668\u5b98\u82af\u7247\u5e03\u5c40\u7684\u9876\u89c6\u56fe\u793a\u51fa\u4e86\u8840\u6db2\u56de\u8def\u4e2d\u76843\u4e2a\u6d4b\u91cf\u70b9\uff08A\uff0cB\u548c C\uff09\u7684\u4f4d\u7f6e\u4ee5\u53ca\u6392\u6cc4\u56de\u8def\u4e2d\u7684\u4e24\u4e2a\u6d4b\u91cf\u70b9\uff08D\uff0cE\uff09\u3002\u8be5\u88c5\u7f6e\u7528\u5fae\u6cf5\u8bbe\u5907\u6765\u63a7\u5236\u6d41\u4f53\u7684\u987a\u65f6\u9488\u548c\u9006\u65f6\u9488\u6d41\u52a8\uff0c\u4ee5\u5fae\u901a\u9053\u76f8\u8fde\u63a5\uff0c\u5728\u82af\u7247\u4e0a\u57f9\u517b\u6784\u5efa\u4e86\u53ef\u5bb9\u7eb3\u80a0\u3001\u809d\u3001\u76ae\u80a4\u3001\u80be4\u4e2a\u5668\u5b98\u7684MOC\u7cfb\u7edf\uff0c\u901a\u8fc7\u4e24\u4e2a\u6d41\u52a8\u56de\u8def\u6a21\u62df\u6a21\u62df\u836f\u7269\u5728\u80a0\u5185\u5438\u6536\u3001\u809d\u810f\u4ee3\u8c22\u4ee5\u53ca\u80be\u810f\u6392\u6cc4\uff0c\u7528\u4e8e\u4f53\u5916\u68c0\u6d4b\u5019\u9009\u836f\u7269\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8bc4\u4f30\u3002\u5e94\u7528\u8be5\u7cfb\u7edf\u4f53\u5916\u6a21\u62df\u4e86\u4eba\u4f53\u5185\u8461\u8404\u7cd6\u4ee3\u8c22\u7684\u73af\u5883\uff0c\u7ed3\u679c\u663e\u793a\u82af\u7247“\u53e3\u670d”\u836f\u7269\uff0c\u5438\u6536\u540e\u836f\u7269\u901a\u8fc7\u6a21\u62df\u7684\u8840\u6db2\u5faa\u73af\uff0c\u7ecf\u8fc7\u809d\u810f\uff0c\u7136\u540e\u8fdb\u5165\u76ae\u80a4\u548c\u80be\u810f\uff0c\u5230\u8fbe\u80be\u810f\u5668\u5b98\u6a21\u578b\u4ee3\u8c22\u5e76\u7ecf\u80be\u5c3f\u6db2\u6392\u51fa\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u8461\u8404\u7cd6\u5728\u5c0f\u80a0\u5185\u7684\u4ee3\u8c22\u9014\u5f84\u3002\u6b64\u5916\uff0c\u8fd8\u6709\u76f8\u5173\u7814\u7a76\u5171\u57f9\u517b\u795e\u7ecf\u7403\u548c\u809d\u7403\u4f53\uff0c\u6784\u5efa\u795e\u7ecf\u7cfb\u7edf-\u809d\u810f\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\uff0c\u75282\uff0c5-\u5df1\u4e8c\u916e\u7814\u7a76\u5176\u5bf9\u7ec4\u7ec7\u7684\u6bd2\u6027\u4f5c\u7528\u548c\u4ee3\u8c22\u9014\u5f84\uff0c\u901a\u8fc7\u6d4b\u5b9a\u8461\u8404\u7cd6\u6d88\u8017\u91cf\u548c\u4e73\u9178\u4ea7\u91cf\u4f5c\u4e3aMOC\u7cfb\u7edf\u4ee3\u8c22\u6d3b\u52a8\u7684\u6307\u6807\u3002\u5728\u809d\u4e2d\uff0c\u6b63\u5df1\u70f7\u53ef\u80fd\u4ee5\u89e3\u6bd2\u9014\u5f84\u6216\u8005\u751f\u7269\u6d3b\u5316\u9014\u5f84\u4ee3\u8c22\u4e3a\u5df1\u9187\uff0c\u7ecf\u8fc7\u8840\u6db2\u5230\u8fbe\u5927\u8111\u4ea7\u751f\u6bd2\u5bb3\u4f5c\u7528\uff0c\u5b9e\u9a8c\u4e2d\u5bf9\u4e24\u79cd\u4e0d\u540c\u6d53\u5ea6\u76842\uff0c5-\u5df1\u4e8c\u916e\u7684\u6bd2\u6027\u6d4b\u5b9a\u7ed3\u679c\u8868\u660e\u5176\u8bf1\u5bfc\u4e86\u795e\u7ecf\u7403\u548c\u809d\u5fae\u7ec4\u7ec7\u4e2d\u7684\u9ad8\u5ea6\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n

\n\t\"\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u6280\u672f\u53ca\u5176\u5e94\u7528\"<\/p>\n

\n\t\u56fe\uff11 \u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u8bbe\u8ba1\u793a\u610f\u56fe<\/p>\n

\n\t\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u7cfb\u7edf\u7814\u7a76<\/strong><\/p>\n

\n\t\u5fae\u7ec6\u80de\u57f9\u517b\u7269\u7c7b\u4f3c\u7269\uff08μCCA\uff09\u4e0ePBPK\u6a21\u578b<\/p>\n

\n\t\u836f\u4ee3\u52a8\u529b\u5b66\u6a21\u578b\uff08Physiologically Based PhARm<\/u>acokinetics, PBPK\uff09\u662f\u6307\u4e00\u79cd\u66f4\u7b26\u5408\u836f\u7269\u5728\u4f53\u5185\u52a8\u6001\u53d8\u5316\u7684\u5177\u4f53\u72b6\u51b5\u7684\u6a21\u578b\uff0c\u5bf9\u4e8e\u65b0\u836f\u7814\u53d1\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002PBPK\u6a21\u578b\u4ee5“\u751f\u7406\u5b66\u5ba4”\u4ee3\u66ff\u7ecf\u5178\u6a21\u578b\u4e2d\u7684\u9694\u5ba4\uff08\u623f\u5ba4\u6a21\u578b\uff09\uff0c\u6839\u636e\u8d28\u91cf\u5e73\u8861\u5173\u7cfb\u3001\u6309\u6a21\u578b\u5efa\u7acb\u901f\u5ea6\u65b9\u7a0b\u3001\u5bf9\u65b9\u7a0b\u7ec4\u8fdb\u884c\u6c42\u89e3\u3001\u5f97\u51fa\u5404\u4e2a\u7ec4\u7ec7\u6216\u5668\u5b98\u7684\u6bd2\u7269\u6d53\u5ea6\u4e0e\u65f6\u95f4\u7684\u5173\u7cfb\uff0c\u53ef\u57fa\u672c\u660e\u786e\u836f\u7269\u5728\u4f53\u5185\u52a8\u6001\u589e\u52a0\u6216\u51cf\u5c11\u7684\u5b9e\u9645\u60c5\u51b5\u3002\u7531\u4e8e\u5fae\u6d41\u4f53\u53ef\u4ee5\u7cbe\u786e\u63a7\u5236\u591a\u4e2a\u9694\u5ba4\u7684\u6d41\u52a8\u548c\u8fde\u63a5\uff0c\u533a\u57df\u5316\u7684\u5fae\u6d41\u4f53\u7cfb\u7edf\u53ef\u4ee5\u4f5c\u4e3aPBPK\u6a21\u578b\u7684\u4f53\u5916\u5e73\u53f0\u3002 <\/p>\n

\n\t\u7ecf\u8fc7\u5bf9\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u7cfb\u7edf\u7684\u7814\u7a76\uff0c\u5f00\u53d1\u4e86\u4e00\u79cd\u6a21\u62df\u4eba\u7c7b\u5bf9\u836f\u7269\u53cd\u5e94\u7684\u9ad8\u901a<\/u>\u91cf\u4f53\u5916\u7cfb\u7edf\uff0c\u5c06\u57fa\u4e8e\u5fae\u6d41\u63a7\u82af\u7247\u7684\u5fae\u7ec6\u80de\u57f9\u517b\u7269\u7c7b\u4f3c\u7269\uff08Microscale Cell Culture Analog, μCCA\uff09\u4e0ePBPK\u6a21\u578b\u7ed3\u5408\u4f7f\u7528\uff0c\u5efa\u7acb\u5bf9\u5e94PBPK\u6570\u5b66\u6a21\u578b\u7684\u7269\u7406\u88c5\u7f6e\uff08μCCA\u88c5\u7f6e\uff09\u3002\u5728\u88c5\u7f6e\u4e2d\uff0c\u6bcf\u4e2a\u5668\u5b98\u4ee3\u8868\u4e00\u4e2a\u9694\u5ba4\uff0c\u4ee3\u8868\u5173\u952e\u5668\u5b98\u7684\u8154\u5ba4\u88ab\u5236\u9020<\/u>\u5728\u7845\u82af\u7247\u4e0a\uff0c\u5e76\u901a\u8fc7\u5fae\u901a\u9053\u76f8\u4e92\u8fde\u63a5\u7528\u4e8e\u6a21\u62df\u8840\u6db2\u6d41\u52a8\u4e2d\u7684\u4ecb\u8d28\u518d\u5faa\u73af\uff0cμCCAs\u7f29\u5c0f\u5668\u4ef6\u53ef\u4ee5\u5728\u4f53\u5916\u6a21\u62df\u8fd1\u751f\u7406\u6d41\u4f53\u6d41\u52a8\u6761\u4ef6\u3001\u4f53\u5185\u7ec4\u7ec7\u7684\u5c3a\u5bf8\u6bd4\u4ee5\u53ca\u591a\u7ec4\u7ec7\u5668\u5b98\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u901a\u8fc7\u4f7f\u7528\u5916\u90e8\u6cf5\u548c\u5916\u90e8\u5e38\u89c1\u7684\u4ecb\u8d28\u518d\u5faa\u73af\u6765\u652f\u6301\u4e2a\u4f53\u809d\u810f\u3001\u9aa8\u9ad3\u548c\u80bf\u7624\u7ec6\u80de\u7cfb\u57f9\u517b\u9694\u5ba4\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u5728\u5bf9\u809d\u810f\u3001\u9aa8\u9ad3\u548c\u80bf\u7624\u7ec6\u80de\u7cfb\u5171\u57f9\u517b\u7814\u7a76\u4e2d\uff0c\u6839\u636e\u4eba\u7c7b\u7ec4\u7ec7\u6570\u636e\u8bbe\u7f6e\u7f29\u653e\u7ec6\u80de\u5ba4\u53ca\u76f8\u5173\u53c2\u6570\uff0cμCCA\u88c5\u7f6e\u4e2d\u4e0d\u540c\u7ec4\u7ec7\u6216\u8005\u5668\u5b98\u5206\u522b\u4ee5\u5355\u72ec\u7684\u9694\u5ba4\u76f8\u8fde\u63a5\u6765\u6a21\u62df\u591a\u7ec4\u7ec7\u5668\u5b98\u7684\u4f5c\u7528\u73af\u5883\u3002\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0cμCCA\u88c5\u7f6e\u80fd\u591f\u6355\u83b7\u809d\u810f\u9694\u5ba4\u4e2d\u7684\u4ee3\u8c22\uff0c\u53ef\u4ee5\u89c2\u5bdf\u5230\u4f20\u7edf\u5b54\u677f\u6d4b\u5b9a\u4e2d\u672a\u89c2\u5bdf\u5230\u7684\u80bf\u7624\u7ec6\u80de\u7684\u635f\u4f24\u3002 <\/p>\n

\n\t\u7ed3\u5408PBPK\u9884\u6d4b\u7684μCCA\u88c5\u7f6e\u53ef\u4ee5\u4e0e\u4eba\u4f53\u8bd5\u9a8c\u7684\u836f\u7269\u5904\u7406\u5339\u914d\uff0c\u4e0d\u4ec5\u80fd\u6a21\u62df\u52a8\u6001\u7684\u591a\u5668\u5b98\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u4e14\u8fd8\u80fd\u591f\u6a21\u62df\u73b0\u5b9e\u7684\u751f\u7406\u5fae\u73af\u5883\uff0c\u5b9e\u73b0\u4f53\u5916\u7814\u7a76\u836f\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7b49\u836f\u6548\u5b66\u6027\u8d28\u3002μCCA\u88c5\u7f6e\u7684\u5fae\u73af\u5883\u662f\u57fa\u4e8e\u4e00\u4e2a\u7b80\u5316\u7684PBPK\u6570\u5b66\u6a21\u578b\u8bbe\u8ba1\u7684\uff0c\u5728\u7814\u7a76\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u4e0d\u540c\u5668\u5b98\u7ec6\u80de\u95f4\u4e92\u4f5c\u53ca\u6bd2\u6027\u548c\u4ee3\u8c22\u76f8\u4e92\u4f5c\u7528\u7684\u5047\u8bbe\u68c0\u9a8c<\/u>\u7b49\u65b9\u9762\u6709\u91cd\u8981\u610f\u4e49\u3002\u4e0d\u8db3\u7684\u662f\uff0c\u5f53\u7ec6\u80de\u4ee5\u6d41\u4f53\u8fde\u63a5\u7684\u65b9\u5f0f\u57f9\u517b\u65f6\uff0c\u57f9\u517b\u57fa\u5728\u63d0\u4f9b\u8425\u517b\u7269\u8d28\u3001\u53bb\u9664\u7ec6\u80de\u5e9f\u7269\u7684\u540c\u65f6\uff0c\u4e5f\u53ef\u80fd\u4f1a\u653e\u5927\u672a\u77e5\u704c\u6ce8\u6db2\u5bf9\u9694\u5ba4\u7ec6\u80de\u7684\u6bd2\u6027\u4f5c\u7528\u3002 <\/p>\n

\n\t\u591a\u901a\u9053\u4e09\u7ef4\u5fae\u6d41\u63a7\u7ec6\u80de\u57f9\u517b\u7cfb\u7edf\uff083D-μFCCS\uff09<\/strong><\/p>\n

\n\t\u7531\u4e8eμCCA\u88c5\u7f6e\u7684\u4e0d\u8db3\uff0c\u8981\u8bbe\u8ba1\u4e00\u4e2a\u4f53\u5185\u9ad8\u5ea6\u4fdd\u5b88\u7684\u7cfb\u7edf\uff0c\u91cd\u8981\u7684\u662f\u4ee5\u6d41\u4f53\u8054\u7cfb\u7684\u65b9\u5f0f\u57f9\u517b\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c\u540c\u65f6\u4fdd\u6301\u5f7c\u6b64\u95f4\u7684\u9694\u79bb\uff0c\u636e\u6b64\u5f00\u53d1\u4e86\u4e00\u79cd\u591a\u901a\u90533D\u5fae\u6d41\u63a7\u7ec6\u80de\u57f9\u517b\u7cfb\u7edf\uff083D microfluidic Cell Culture Syste<\/u>m, 3D-μFCCS\uff09\u3002<\/p>\n

\n\t3D-μFCCS\u662f\u7531\u591a\u4e2a\u5fae\u901a\u9053\u76f8\u4e92\u8fde\u63a5\u7684\u5fae\u6d41\u4f53\u901a\u9053\u548c\u5fae\u9635\u5217\u7ec4\u6210\uff0c\u91c7\u7528\u5fae\u9635\u5217\u6280\u672f\u5bf9\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\u8fdb\u884c\u9ad8\u5bc6\u5ea6\u7269\u7406\u56fa\u5b9a\uff0c\u4ee5\u83b7\u5f97\u6700\u5927\u7684\u7ec6\u80de-\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u3002\u57283D\u7403\u5f62\u5fae\u7ec4\u7ec7\u548c\u5fae\u6d41\u63a7\u6280\u672f\u8fdb\u884c\u591a\u7ec4\u7ec7\u5b9e\u9a8c\u5206\u6790\u4e2d\uff0c\u5c06\u9884\u5148\u5f62\u6210\u7684\u7403\u5f62\u5fae\u7ec4\u7ec7\u88c5\u8f7d\u5230\u5fae\u5ba4\u4e2d\u5e76\u5728\u8fde\u7eed\u704c\u6ce8\u4e0b\u57f9\u517b\uff0c\u901a\u8fc7\u81ea\u52a8\u5316\u7684\u82af\u7247\u503e\u659c\u7531\u91cd\u529b\u9a71\u52a8\u7684\u6d41\u52a8\u4ea7\u751f\uff0c\u800c\u4e0d\u9700\u8981\u989d\u5916\u7684\u7ba1\u9053\u548c\u5916\u90e8\u6cf5\u3002\u4ee53D-μFCCS\u4e3a\u57fa\u7840\u6784\u5efa\u7684\u9f20\u809d\u548c\u5927\u80a0\u80bf\u7624MOC\u7cfb\u7edf\u5728\u524d\u4f53\u836f\u7269\u73af\u78f7\u9170\u80fa\u5b58\u5728\u4e0b\u57f9\u517b8d\uff0c\u4ec5\u5728\u82af\u7247\u4e0a\u4e0d\u540c\u5fae\u91cf\u7ec4\u7ec7\u7c7b\u578b\u7684\u5171\u57f9\u517b\u7269\u4e2d\u89c2\u5bdf\u5230\u5bf9\u80bf\u7624\u751f\u957f\u6709\u663e\u8457\u5f71\u54cd\uff0c\u800c\u73af\u78f7\u9170\u80fa\u5904\u7406\u7684\u9759\u6001\u809d\u810f\u5fae\u7ec4\u7ec7\u7684\u4e0d\u8fde\u7eed\u8f6c\u79fb\u4e0a\u6e05\u6db2\u5e76\u4e0d\u663e\u8457\u5f71\u54cd\u80bf\u7624\u751f\u957f\u3002\u8be5\u7cfb\u7edf\u9a8c\u8bc1\u4e86\u73af\u78f7\u9170\u80fa\u5bf9\u80bf\u7624\u751f\u957f\u6709\u663e\u8457\u7684\u5f71\u54cd\uff0c\u4f46\u5728\u4f53\u5916\u65e0\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u53ea\u6709\u5728\u809d\u810f\u88ab\u751f\u7269\u6d3b\u5316\u4e4b\u540e\u624d\u8d77\u4f5c\u7528\u3002 <\/p>\n

\n\t\u6b64\u5916\uff0c\u591a\u901a\u90533D-μFCCS\u8fd8\u88ab\u8bbe\u8ba1\u7528\u4e8e\u540c\u65f6\u57f9\u517b\u4e0d\u540c\u5668\u5b98\u7684\u7ec6\u80de\u805a\u96c6\u4f53\u4ee5\u6a21\u62df\u8eab\u4f53\u4e2d\u7684\u591a\u4e2a\u5668\u5b98\u3002\u57f9\u517b4\u79cd\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\uff0c\u4ee5\u6a21\u62df\u4eba\u7c7b\u76844\u79cd\u5668\u5b98\uff1aC3A\uff08\u809d\u810f\uff09\uff0cA549\uff08\u80ba\u810f\uff09\uff0cHK-2\uff08\u80be\u810f\uff09\u548c HPA\uff08\u8102\u80aa\uff09\uff0c\u901a\u8fc7\u8865\u5145\u5e38\u89c1\u7684\u57f9\u517b\u57fa\u4e0e\u751f\u957f\u56e0\u5b50\u6765\u4f18\u5316\u7ec6\u80de\u529f\u80fd\u3002\u5728\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\u4e2d\uff0c\u7279\u5f02\u6027\u5730\u5c06TGF-β1\u5728A549\u5ba4\u5185\u63a7\u5236\u91ca\u653e\uff0c\u80fd\u589e\u5f3aA549\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u800cC3A\u3001HK-2\u548cHPA\u7ec6\u80de\u7684\u529f\u80fd\u4e0d\u53d7\u5f71\u54cd\uff0c\u4e0e\u6a21\u62df\u5355\u4e2a\u7ec4\u7ec7\u529f\u80fd\u6709\u6240\u4e0d\u540c\u30023D-μFCCS\u88c5\u7f6e\u4e0a\uff0c\u7ec6\u80de\u57f9\u517b\u9694\u5ba4\u4e4b\u95f4\u6709\u9650\u7684\u76f8\u4e92\u4f5c\u7528\u7c7b\u4f3c\u4e8e\u4f53\u5185\u7684\u60c5\u51b5\u3002 <\/p>\n

\n\t\u5355\u5411\u6d41\u52a8\u7684\u751f\u7269\u6d4b\u5b9a\u7cfb\u7edf\u53ca\u5176\u4ed6MOC\u7cfb\u7edf<\/strong><\/p>\n

\n\t\u76f8\u6bd4μCCA\u548c3D-μFCCS\uff0cImura\u53ca\u5176\u540c\u4e8b\u6784\u5efa\u7684\u751f\u7269\u6d4b\u5b9a\u7cfb\u7edf\u662f\u76f8\u5bf9\u5148\u8fdb\u7684\u7248\u672c\uff0c\u5b83\u5c06\u4eba\u7c7b\u7684\u80a0\u9053\uff0c\u809d\u810f\u548c\u4e73\u817a\u764c\u7ec6\u80de\u7cfb\u57f9\u517b\u7269\u7ec4\u5408\u6210<\/u>\u4e00\u4e2a\u5355\u4e00\u7684\u7ebf\u6027\u901a\u9053\uff0c\u5e94\u7528\u5355\u5411\u6d41\u52a8\u800c\u4e0d\u9700\u8981\u4ecb\u8d28\u518d\u5faa\u73af\u3002\u5fae\u82af\u7247\u7531\u8f7d\u73bb\u7247\uff0c\u900f\u6c14\u819c\u548c\u805a\u4e8c\u7532\u57fa\u7845\u6c27\u70f7\u7247\u7ec4\u6210\uff0c\u5176\u4e2d\u542b\u6709\u901a\u8fc7\u5149\u523b\u5236\u6210\u7684\u5fae\u901a\u9053\u3002\u5c06Caco-2\u514b\u9686\u7ed3\u80a0\u817a\u764c\u7ec6\u80de\u5728\u5fae\u82af\u7247\u7684\u819c\u4e0a\u57f9\u517b\uff0c\u6a21\u62df\u836f\u7269\u7684\u4f53\u5185\u80a0\u8f6c\u8fd0\uff1a\u73af\u78f7\u9170\u80fa\u80fd\u900f\u8fc7\u80a0\u5c4f\u969c\u7684\uff0c\u8868\u73b0\u51fa\u8f83\u9ad8\u7684\u6e17\u900f\u7cfb\u6570\uff0c\u73af\u78f7\u9170\u80fa\u4e0d\u80fd\u88ab\u80a0\u58c1\u5438\u6536\u7684\uff0c\u8868\u73b0\u51fa\u8f83\u4f4e\u7684\u6e17\u900f\u7cfb\u6570\u3002\u6e17\u900f\u6d4b\u8bd5<\/u>\u7ed3\u679c\u4e0e\u4f7f\u7528\u4f20\u7edf\u65b9\u6cd5\u83b7\u5f97\u7684\u7ed3\u679c\u4e00\u81f4\uff0c\u800c\u7535\u6c60<\/u>\u6d88\u8017\u51cf\u5c1180%\u3002<\/p>\n

\n\t\u8fd1\u5e74\u6765\uff0c\u5728\u539f\u6709\u5668\u5b98\u82af\u7247\u7cfb\u7edf\u7684\u57fa\u7840\u4e0a\uff0cMOC\u7cfb\u7edf\u8fdb\u4e00\u6b65\u53d1\u5c55\u5b8c\u5584\u3002Loskill\u7b49\u5229\u7528μOrgano\u7cfb\u7edf\u7814\u7a76\u591a\u4e2a\u5fc3\u810f\u5355\u5143\uff0c\u53ef\u4ee5\u5355\u72ec\u52a0\u8f7d\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\uff0c\u63a7\u5236\u5206\u5316\u548c\u53d1\u80b2\u7684\u65f6\u95f4\uff0c\u63a7\u5236\u5404\u4e2a\u7ec4\u7ec7\u7684\u6d41\u4f53\u8fde\u63a5\uff0c\u5373\u63d2\u5373\u7528\u3002Maschmeyer\u7b49\u8bbe\u8ba1\u4e86\u53ef\u5bb9\u7eb3\u4e24\u4e2a\u5fae\u751f\u7269\u6d41\u4f53\u6d41\u52a8\u56de\u8def\u7684MOC\u88c5\u7f6e\uff0c\u9996\u6b21\u5b9e\u73b0\u4e86\u80a0\u3001\u809d\u3001\u76ae\u80a4\u548c\u80be4\u4e2a\u5668\u5b98\u7ec4\u7ec7\u5728\u5fae\u6d41\u63a7\u82af\u7247\u4e0a\u91cd\u590d\u57f9\u517b28d\uff0c\u4e14\u6240\u6709\u7ec4\u7ec7\u5728\u6574\u4e2a\u5171\u57f9\u517b\u671f\u95f4\u4fdd\u6301\u9ad8\u7ec6\u80de\u6d3b\u529b\u548c\u79bb\u6563\u7684\u751f\u7406\u7ec4\u7ec7\u7ed3\u6784\uff0c\u6210\u529f\u4ece\u751f\u7406\u89d2\u5ea6\u8bc1\u660e\u4e86\u80a0\u9053\u7684\u529f\u80fd\u4ee5\u53ca\u80be\u810f\u7684\u751f\u7269\u5c4f\u969c\u3002\u9664\u4e86\u80a0\u5c4f\u969c\u4e0e\u80be\u5c4f\u969c\uff0c\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u8fd8\u6210\u529f\u5730\u6a21\u62df\u4e86\u4eba\u4f53\u7684\u591a\u4e2a\u751f\u7269\u5c4f\u969c\uff0c\u4f8b\u5982\u5229\u7528Transwell\u88c5\u7f6e\u5728\u60ac\u6d6e\u4e8e\u5b54\u4e2d\u7684\u6ee4\u819c\u4e0a\u57f9\u517b\u7ec6\u80de\u6a21\u62df\u8840\u8111\u5c4f\u969c\u8fdb\u884c\u836f\u7269\u8f6c\u8fd0\u7814\u7a76\u53ca\u68c0\u6d4b\u7279\u5b9a\u6807\u5fd7\u7269\u7684\u8868\u8fbe\uff0c\u5728\u6c14\u6db2\u754c\u9762\u5b9e\u73b0\u80ba\u4e0a\u76ae\u7ec6\u80de\u4e0e\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u5171\u57f9\u517b\u7684\u6c14\u8840\u5c4f\u969c\u7b49\u3002<\/p>\n

\n\t\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u7684\u8bbe\u8ba1\u53ca\u65b0\u5e94\u7528<\/strong><\/p>\n

\n\t\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u8bbe\u8ba1<\/p>\n

\n\t\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u7684\u8bbe\u8ba1\u57fa\u4e8ePBPK\u7684\u7406\u5ff5\uff0c\u53ef\u5229\u7528\u6a21\u578b\u9884\u6d4b\u4eba\u4f53\u5bf9\u836f\u7269\u7684\u53cd\u5e94\u4ee5\u53ca\u836f\u7269\u7684\u4f5c\u7528\u673a\u5236\u3002\u6700\u5e38\u5236\u9020\u7684\u88c5\u7f6e\u662f\u5c3a\u5bf8\u572810~200mm\u4e4b\u95f4\u7684\u5fae\u6d41\u4f53\u901a\u9053\uff0c\u9694\u5ba4\u7684\u5927\u5c0f\u6839\u636e\u5176\u529f\u80fd\u6b63\u786e\u5730\u8bbe\u8ba1\u6bd4\u4f8b\uff0c\u4e0d\u540c\u7684\u5668\u5b98\u529f\u80fd\u6839\u636e\u5176\u673a\u5236\u7684\u4e0d\u540c\u800c\u5177\u6709\u4e0d\u540c\u7684\u5c3a\u5ea6\u3002\u5fae\u6d41\u4f53\u7cfb\u7edf\u6750\u6599\u901a\u5e38\u91c7\u7528\u805a\u4e8c\u7532\u57fa\u7845\u6c27\u70f7\uff0c\u4f18\u5316\u540e\u591a\u7528\u591a\u5b54\u6027\u8f83\u597d\u7684\u6c34\u51dd\u80f6\uff0c\u53ef\u5141\u8bb8\u6c34\u51dd\u80f6\u652f\u67b6\u5185\u7684\u5206\u5b50\u6269\u6563\u3002\u82af\u7247\u5236\u4f5c\u540e\u9700\u8981\u9274\u5b9a\u548c\u6d4b\u91cf\u57f9\u517b\u7684\u7ec4\u7ec7\u5728\u7528\u836f\u7269\u6216\u5de5\u7a0b\u523a\u6fc0\u7269\u5904\u7406\u65f6\u7684\u529f\u80fd\u53cd\u5e94\uff0c\u8fdb\u884c\u7ec6\u80de\u6d3b\u529b\u3001\u673a\u68b0\u529b\u3001\u7535\u4fe1\u53f7\u68c0\u6d4b\u4ee5\u53ca\u5316\u5b66\u5206\u6790\u7b49\u3002 <\/p>\n

\n\t\u76ee\u524d\uff0c\u8bbe\u8ba1\u5fae\u6d41\u63a7\u82af\u7247\u4f53\u7cfb\u4e3b\u8981\u4f7f\u7528PBPK\u6a21\u578b\u548cPD\u6a21\u578b\u3002\u5728PBPK\u6a21\u578b\u4e2d\uff0c\u836f\u4ee3\u52a8\u529b\u5b66 \uff08Pharmacokinetics, PK\uff09\u5efa\u6a21\u7684\u65b9\u6cd5\u7528\u6765\u8bbe\u8ba1\u548c\u64cd\u4f5c\u4ee5\u518d\u73b0\u591a\u5668\u5b98\u76f8\u4e92\u4f5c\u7528\u3002PK\u5efa\u6a21\u53ef\u91cf\u5316\u8eab\u4f53\u4e0d\u540c\u90e8\u4f4d\u7684\u836f\u7269\u91cf\uff0c\u53ef\u7528\u7b80\u5355\u7684\u672f\u8bed\u6765\u63cf\u8ff0\u836f\u7269\u7ed9\u836f\u540e\u5438\u6536\u3001\u5206\u5e03\u3001\u4ee3\u8c22\u548c\u6d88\u9664\u7684\u590d\u6742\u8fc7\u7a0b\uff0c\u5e76\u6df1\u5165\u4e86\u89e3\u836f\u7269\u5206\u5e03\u52a8\u529b\u5b66\u3002\u7136\u800c\uff0c\u5efa\u7acb\u4e00\u4e2a\u751f\u7406\u5b66\u4e0a\u51c6\u786e\u7684\u6a21\u578b\u662f\u5341\u5206\u56f0\u96be\u7684\uff0c\u56e0\u6b64\u9650\u5236\u4e86PK\u5efa\u6a21\u7684\u5e7f\u6cdb\u4f7f\u7528\u3002\u836f\u6548\u52a8\u529b\u5b66\uff08Pharmacodynamics, PD\uff09\u5efa\u6a21\u4e2d\u836f\u7406\u5b66\u4f5c\u7528\u88ab\u89c6\u4e3a\u836f\u7269\u6d53\u5ea6\u7684\u51fd\u6570\uff0c\u662f\u9488\u5bf9\u836f\u7269\u5728\u4f53\u5185\u7684\u836f\u7406\u4f5c\u7528\u7684\u7814\u7a76\u6a21\u578b\u3002\u5355\u72ec\u7684PK\u6a21\u578b\u4e0d\u80fd\u9610\u660e\u65f6\u95f4-\u836f\u6548\u7684\u5173\u7cfb\uff0c\u5355\u72ec\u7684PD\u6a21\u578b\u4e5f\u4e0d\u80fd\u9610\u660e\u65f6\u95f4-\u6d53\u5ea6\u7684\u5173\u7cfb\uff0c\u56e0\u6b64\u9700\u8981\u7ed3\u5408\u4e24\u8005\u5efa\u7acbPK-PD\u6a21\u578b\u4ee5\u7814\u7a76\u836f\u7269\u4f5c\u7528\u9776\u90e8\u4f4d\u7684\u6d53\u5ea6-\u6548\u5e94-\u65f6\u95f4\u4e09\u7ef4\u5173\u7cfb\u3002\u5728PBPK-PD\u6a21\u578b\u4e2d\uff0cPD\u6a21\u578b\u4e0ePK \u6a21\u578b\u8026\u5408<\/u>\uff0c\u4f7f\u7528\u7ec4\u5408\u7684PK-PD\u6a21\u578b\u6765\u9884\u6d4b\u6216\u5206\u6790\u7ed9\u5b9a\u5242\u91cf\u836f\u7269\u7684\u751f\u7406\u6548\u5e94\uff0c\u7efc\u5408PK-PD\u6a21\u578b\u53ef\u4ee5\u8bc4\u4f30\u7279\u5b9a\u5242\u91cf\u4e0b\u836f\u7269\u7684\u751f\u7406\u7ed3\u679c\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u53d8\u5316\uff0c\u5e94\u7528\u6027\u76f8\u5bf9\u8f83\u5e7f\u6cdb\u3002<\/p>\n

\n\t\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u7684\u65b0\u5e94\u7528<\/strong><\/p>\n

\n\t\u968f\u7740\u591a\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247\u5728\u836f\u7269\u4ee3\u8c22\u65b9\u9762\u5e94\u7528\u7814\u7a76\u7684\u6df1\u5165\uff0c\u4e5f\u4ea7\u751f\u4e86\u5404\u79cd\u65b0\u5e94\u7528\uff0c\u5982\u5229\u7528\u80ba\u5668\u5b98\u82af\u7247\u7814\u7a76\u7eb3\u7c73\u6750\u6599\u6bd2\u6027\u53ca\u4ee3\u8c22\u3002\u54c8\u4f5b\u5927\u5b66\u901a\u8fc7\u7814\u7a76\u80ba\u5bf9\u8367\u5149\u7eb3\u7c73\u9897\u7c92\u4f20\u9012\u81f3\u80ba\u4e0a\u76ae\u7ec6\u80de\u5f15\u53d1\u7684\u4e00\u7cfb\u5217\u6bd2\u6027\u53cd\u5e94\uff0c\u6765\u63a2\u7a76\u5e94\u7528\u4e8e\u73af\u5883\u6bd2\u7406\u5b66\u7684\u80ba\u82af\u7247\u7cfb\u7edf\u7684\u6f5c\u5728\u4ef7\u503c\uff0c\u4e3a\u73af\u5883\u6c61\u67d3<\/u>\u7269\u7684\u4f53\u5185\u4ee3\u8c22\u6a21\u62df\u7814\u7a76\u5f00\u62d3\u4e86\u65b0\u7684\u89c6\u91ce\u3002 <\/p>\n

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\n\t\u5c55\u671b<\/strong><\/p>\n

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